Azelaic acid

Research use only, not for human use.

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.

Cell Viability AssayCell Line:Propionibacterium acnes and Staphylococcus epidermidis Concentration:0.5 M Incubation Time: Propionibacterium acnes for 48 h, Staphylococcus epidermidis for 7 D Result:Exhibited large reduction in viability (at least 40-fold) over 24 h.Immunofluorescence Cell Line:HL60, U937, THP-1, and AML-PC cells Concentration:5 M Incubation Time:24 hResult:Exhibited markedly decreasing the intracellular ROS levels.Cell Viability Assay Cell Line:B16, HMB2, and SK23, CHO Concentration: 10 nM, 20 nM, 30 nM, 40 nM, 50 nM, 60 nM, 70 nM, 80 nM, 90 nM, 100 nM Incubation Time: 24 h Result:Showed significantly reduce in the number of B16, HMB2, and SK23 comparing to CHO.

Animal Model:Human with rosacea for 12 weeks Dosage:15% gel Administration:Smear Result:Showed excellent improvent in 78% of the patients with Azelaic acid.

NSC 19493

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA polymerase I| ThxR

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123-99-9

188.22

C9H16O4

>98% (HPLC)

soluble in Water

OC(=O)CCCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years